![]() ![]() The model has been highly accurate to date, successfully predicting, among others, the failure of hydroxychloroquine and the success of remdesivir before the results of clinical trials testing these therapies were announced.įunding was provided by the Parsemus Foundation, Rainwater Charitable Foundation, Fast Grants and the United Health Foundation. Metformin’s ability to stop the virus was predicted by a simulator developed by U of M Medical School and College of Science and Engineering Biomedical Engineering faculty. Further research could show whether it is also effective in those with previous infection or in adults with lower body mass index.” “While half of our trial had been vaccinated, none had been previously infected with the COVID-19 virus. Bramante, who is also an internist and pediatrician with M Health Fairview. “This long-term outcome from a randomized trial is high-quality evidence that metformin prevents harm from the SARS-CoV-2 virus,” said Dr. Over 1,100 of the participants reported on their symptoms for up to 10 months after their initial COVID-19 diagnosis. Participants were between 30 and 85 years old who qualified as overweight or obese. The study included more than 1,200 participants who were randomly chosen to receive either metformin or placebo, and an additional subset received ivermectin, fluvoxamine or their placebos. The UNC School of Medicine was not a site for the clinical trial. Caviness Distinguished Professor of Medicine and senior associate dean for clinical research at the UNC School of Medicine.īuse, who co-led the conception, design and oversight of the study, is the director of the NC Translational and Clinical Sciences ( NC TraCS) Institute. “Not only did we demonstrate that metformin, an inexpensive and safe treatment, may prevent the development of long COVID in many people, but we validated that long COVID is a real disease in that a 14-day treatment can reduce the risk of long COVID symptoms and a doctor’s diagnosis over many months,” said John Buse, MD, PhD, the Verne S. Ivermectin and fluvoxamine did not prevent long COVID. ![]()
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